Additionally, and also supporting αSyn-induced cofilin-1 inactivation, in a glaucoma animal model, consisting on elevated intraocular pressure which results in retinal neurodegeneration, the intravitreal injection of αSyn antibodies hampered neurodegeneration, an effect that was suggested to involve upregulation of cofilin-1 (Teister et al., 2017). Here, CFL1 is linked to glaucoma.