CFL1 and Parkinson disease: In this respect, a report using a PD Drosophila model based on the neuronal overexpression of αSyn, validated the pathologic impact of the protein on the actin cytoskeleton, as αSyn transgenic flies showed increased F-actin and the presence of rod-shaped actin-cofilin rich inclusions in whole-mounted brains (Ordonez et al., 2018).