Importantly, this outcome was recapitulated using fibroblasts from PD patients carrying multiplications of the SNCA gene (Bellani et al., 2014), which presented a threefold increase in the phospho-cofilin 1/cofilin 1 ratio and an increased number and thickness of actin stress fibers structures (Bellani et al., 2014). This evidence concerns the gene CFL1 and Parkinson disease.