In vivo study with fucoxanthin and its metabolite’s actions against the characteristics associated with obesity, demonstrated reduction of serum and hepatic levels of triglycerides and inflammatory cytokines like PGE2, nitric oxide, IL-1, and TNF-α (Sakai et al., 2009; Hu et al., 2012). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.