Furthermore, adiponectin and HO-1 both serve to act on inhibiting AMPK pathway, which is profound in obesity associated inflammation (Hosick and Stec, 2012; Sodhi et al., 2015; Smith et al., 2016; Achari and Jain, 2017). The gene discussed is HMOX1; the disease is obesity due to melanocortin 4 receptor deficiency.