The mRNA levels of obesity-related inflammation genes like F4/80, TNFα, CD11c, MCP1 and IL6 were lower in these SOD3-administered mice and hepatic de novo lipogenesis genes like SREBP1c, fatty acid synthase and Scd1 were higher in mice that were just given a high fat diet (Cui et al., 2014). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.