CX3CL1 and colorectal carcinoma: The results of an analysis of stimulatory immune-related genes (Figures 3D,E), such as chemokines (CX3CL1, CXCL9, and CXCL10), cytokines (IFNG, IL1B, etc.), and tumor necrosis factor receptor superfamily (TNFRSF)-related genes, indicated significant upregulation in MSI-H CRC (all P < 0.05).