The TME has also become one of the most important factors affecting immunotherapy, and it includes TILs, antigen-presenting cells, Tregs, chemokines, cytokines, etc. In MSI-H CRC, chemokines such as CXCL9, CXCL10 and CXCL11 recruit and activate cytotoxic T lymphocytes (CTLs), DCs, and NK cells in the tumor tissue to exert an antitumor effect. The gene discussed is CXCL9; the disease is neoplasm.