CD4 and colon adenocarcinoma: The results showed that both MSI-H CRC and COAD had an inflammatory TME, as indicated by significantly increased numbers of plasma cells, CD8 + T cells, activated memory CD4 + T cells, follicular T helper cells, NK cells, M1 macrophages and neutrophils and significantly decreased numbers of Tregs (Figures 2L,M, all P < 0.05).