IFNG and neoplasm: We found that the prolonged OS of MSI-H patients after ICI treatment might be related to increased tumor immunogenicity (such as increased NAL, TMB, number of DDR pathway mutations and the expression of antigen processing and presentation-related genes), the significantly upregulated expression of immune-related genes (immune cell-, CYT-, cytokine-, chemokine-, and immune checkpoint-related genes), and elevated immune-related scores (leukocyte fraction score, leukocyte infiltration signature score, and IFN-gamma response).