CD4 and Sepsis: Similar to what was observed with the reduction in proliferative capacity seen 2 days post-CLP-induced sepsis, the frequency and number of single or multi-cytokine producing 2W1S-specific memory CD4 T cells (IFNγ+-, IFNγ+TNF+-, and IFNγ+TNF+IL-2+) was significantly reduced at 2 days post-surgery (Figures 5C,D) and remained reduced 30 days after CLP.