CD4 and Sepsis: The cohoused mice showed a significant reduction in number of Ag-experienced (CD11+CD4d+) and naïve (CD11a−CD49d−) CD4 T cells in the spleen 2 days after CLP that returned to sham levels by day 30 (Figures 3B–E), indicating entire CD4 T cell compartment is susceptible to sepsis-induced numerical reduction.