Immunoblot analysis showed a statistically significant increase in FMO3 protein expression in 8-month-old 3×Tg-AD and db/db mice in comparison to control mice (t(4) = 19.50, p = 0.0001, and (t(4) = 18.98, p = 0.0001 respectively, Figure 1C). The gene discussed is FMO3; the disease is Alzheimer disease.