We also observed a statistically significant increase in phosphorylation of PERK (t(4) = 16.59, p = 0.0001, Figure 5B) in 3×Tg-AD mice and in db/db mice (t(4) = 10.01, p = 0.0006, Figure 5B) in comparison to control mice. This evidence concerns the gene EIF2AK3 and Alzheimer disease.