In addition we also observed an increased phosphorylation of eIF2α at Serine 51 in 3×Tg-AD (t(4) = 11.54, p = 0.0003, Figure 5B) and db/db mice (t(4) = 9.74, p = 0.004, Figure 5B), and ATF4 expression (data not shown). Here, ATF4 is linked to Alzheimer disease.