We note here, in the study of Seo et al. (41), deletion of Trpc6 was only protective against cardiac remodeling in combination with deletion of Trpc3 and two other studies using pressure overload to model HF in mice have identified Trpc3 as a driver of maladaptive cardiac remodeling (42) and fibrosis (43). This evidence concerns the gene TRPC3 and hydrops fetalis.