In line with animal models where higher TRPC6 expression led to pathologic remodeling, hypertrophic cardiomyopathy, and heart failure (40) our study identified genetic variants that were associated with higher TRPC6 cardiac expression that occurred more frequently in patients with CRHF and in patients with HF of all causes. The gene discussed is TRPC6; the disease is hypertrophic cardiomyopathy.