To our knowledge TRPC6 has not previously been identified as a risk locus in published GWAS studies of HF, although there is a single report of TRPC6 associated with diastolic blood pressure (48), in which rs61892344-T is associated with both diastolic blood pressure and higher TRPC6 expression in the tibial artery (p = 2.6 × 10−17) and artery from aorta (p = 2.9 × 10−6). Here, TRPC6 is linked to hydrops fetalis.