Given the indirect nature of GWAS, the known association of rare missense variants in TRPC6 with the genetic form of chronic kidney disease, focal segmental glomerular sclerosis (FSGS) (24, 25), and the fact that FSGS can result from exposure to anthracyclines (26), we sequenced the coding regions of TRPC6 in 38 patients with CRHF. This evidence concerns the gene TRPC6 and chronic kidney disease.