Moreover, miR-215-3p with a negative regulatory effect on leptin and SLC2A5 influenced the expression of their signaling molecules, including VEGF, Notch-1, p-Stat3, p-JAK2, STYXL1, and FLAD1. The functional results further verified that inhibiting the expression of lnc-REG3G-3-1 or increasing the expression of miR-215-3p can inhibit the tumor metastasis of LADC. Here, STAT3 is linked to neoplasm.