Table 1 summarizes antigen targets for pediatric brain tumors including pHGG. While pediatric clinical trials are in progress that include these antigens, recruitment is more limited due to the difference in antigen expression seen between adult and pediatric high-grade gliomas. However, some activity has been seen in the pediatric population. A prospective trial including 17 adult and adolescent patients with relapsed or refractory glioblastoma included an adolescent patient with an objective response after systemically administered HER2 CAR T cells (132). Here, ERBB2 is linked to central nervous system cancer.