On the other hand, dealing with the predictive value of PD-L1 expression for an enhanced response to immunotherapy with PD1/PD-L1 inhibitors, the global burden of evidence collected in several tumors showed that a higher expression of PD-L1 may be able to predict the responsiveness to ICIs, even though in most cancers the relevance of this correlation is insufficient to validate PD-L1 as a predictive biomarker potentially applicable in the clinical setting (31, 32). Here, CD274 is linked to cancer.