Interestingly, it was reported that the expression of PD-L1 on tumor cells correlated with a higher infiltration of T CD8+ cells in the microenvironment of RCC, with potential implications for prognosis (54), that is influenced even by the presence and grade of activation of dendritic cells in the tumor, able to drive the anti-tumor immune reaction (60). This evidence concerns the gene CD274 and renal cell adenocarcinoma.