Finally, in the KEYNOTE-426 trial, the combination of pembrolizumab plus axitinib showed a benefit over sunitinib in terms of PFS, OS and ORR, irrespectively of PD-L1 expression (assessed with the combined score, including tumor cells, lymphocytes and macrophages), although the hazard ratios for PFS and OS seemed to underline an enhanced advantage in PD-L1 ≥1 versus <1 subgroups [0.62 (95%CI 0.47–0.80) versus 0.87 (95%CI 0.62–1.23) for PFS and 0.54 (95%CI 0.35–0.84) versus 0.59 (95%CI 0.34–1.03) for OS] (16). This evidence concerns the gene CD274 and neoplasm.