CD274 and renal cell adenocarcinoma: Furthermore, in a metanalysis including more than 1300 patients, the expression of PD-L1 in RCC seemed to confer a poorer outcome, approximately doubling the risk of death, and this finding was confirmed after the restriction of the analysis to patients affected by clear cell histology RCC, in case of advanced disease and in cases in which PD-L1 was evaluated uniquely with IHC (30).