CD274 and non-small cell lung carcinoma: On the other hand, in advanced NSCLC, the results of the recent studies evidenced how the IHC expression of PD-L1 and its cutoff are fundamental in the therapeutic decision-making of the non-oncogene-addicted disease, whether choosing the anti-PD1 monotherapy, chemotherapy or the combination of chemotherapy and immunotherapy in first-line (35).