For example, pdoplanin, expressed on cancer associated fibroblasts and tumor cells, is a major ligand to attract platelets by binding to C-type lectin-like receptor 2 (CLEC-2), which has been identified as a receptor for the platelet activating snake venom protein rhodocytin, then facilitates hematogenous cancer metastasis and cancer associated thrombosis (32). This evidence concerns the gene CLEC1B and cancer.