First, we analyzed the expression levels of 11 members in HCC using TCGA data (Figure 1) and found that HDAC1, HDAC2, HDAC3, HDAC8, HDAC5, HDAC7, HDAC10, and HDAC11 were significantly upregulated in TCGA HCC tissues compared with TCGA normal controls. This evidence concerns the gene HDAC8 and hepatocellular carcinoma.