HDAC11 and neoplasm: Collectively, the current findings elucidated the key roles of HDAC11 in mediating sorafenib resistance and tumor metastasis; miR-145-5p was an upstream regulatory miRNA of HDAC11 in sorafenib resistance and metastasis of HCC; and HDAC11 promoter hypomethylation was also responsible for HDAC11 upregulation in HCC (Figure 8).