Moreover, miR-145-5p inhibition markedly promoted HCC cell sorafenib resistance, migration, and invasion, and knockdown of HDAC11 could statistically attenuate miR-145-5p suppression-mediated enhancement of sorafenib resistance and tumor metastasis in HCC, and miR-145-5p overexpression led to opposite effects (Figures 6G–J and Supplementary Figure S7). The gene discussed is HDAC11; the disease is hepatocellular carcinoma.