Promoter hypomethylation and downregulated miR-145-5p commonly mediated HDAC11 overexpression in HCC; knockdown of HDAC11 could reverse HCC cells resistance to sorafenib and suppress metastasis of HCC cells in vitro; miR-145-5p downregulation promoted sorafenib resistance and metastasis in vitro, and these effects could be attenuated after inhibition of HDAC11. The gene discussed is HDAC11; the disease is hepatocellular carcinoma.