RBFOX3 and neoplasm: Moreover, E-cadherin, an important protein involved in tumor metastasis, was downregulated, while β-catenin was markedly elevated upon RBFOX3 overexpression (SGC-7901 cells) (p < 0.05, Figure 3G), suggesting that perturbation in the expression of these proteins may be associated with RBFOX3 and mediate GC processes.