APP and neoplasm: Similar trends were observed in vivo where oAd-vp53/APP induced more potent tumor growth inhibition than naked oAd-vp53, PTX, APP, or oAd-vp53 + PTX treatments through an increase in viral replication, PTX accumulation, and induction of apoptosis in tumor tissues, showing that synergistic efficacy of combination therapy regimen can greatly augmented by a concomitant delivery via a single polymeric system.