Notably, oAd-vp53/APP complex elicited more potent cancer cell killing effect than naked oAd-vp53, oAd-vp53 complexed with ABP, APP treatment, or naked oAd-vp53 in combination with PTX (oAd-vp53 + PTX), showing that concurrent delivery of oAd and APP as a single hybrid vector can enhance the synergistic anticancer effect to a greater extent than a simple co-administration approach. This evidence concerns the gene APP and cancer.