e., overexpression of IFI16 in otherwise negative cells or IFI16 delocalization to the cytoplasm—has been reported in a number of inflammatory conditions, such as SLE (skin) [8], psoriasis (skin) [11–13], SSc (skin) [10], IBD (colonic epithelium) [6,7] and SS (salivary epithelial and inflammatory infiltrating cells) [14,15,17]. This evidence concerns the gene IFI16 and systemic sclerosis.