Fatty acid synthase (FASN) as a key enzyme participated in the fatty acid biosynthetic pathway, and Over expression of FASN protein was observed in over half of BE patients, especially in the intestinal mucin phenotype of Barrett’s esophagus in which glandular cells display increased proliferation, angiogenesis, and COX-2 expression; Further FASN over expression pattern was retained in EAC [38]. Here, FASN is linked to Barrett esophagus.