Fatty acid biosynthesis (2.238E-12), Hippo signaling pathway (2.604E-06), ErbB signaling pathway (1.001E-04) were top ranked as the most prominent pathways enriched in quantiles with the serum miRNA signature (Supplementary Table 1), suggesting that these biologic pathways were involved in the sequential progression of BE to EAC. Here, EGFR is linked to Barrett esophagus.