These changes may be due to rough or violent, nonconsensual vaginal or anal intercourse; genital injuries, such as abrasions, tears, and microlesions in the epithelium of the vagina, cervix, or anal regions; sexually transmitted infections (STIs) that cause cell death; mucosal inflammation; and local activation of CD4+ T cells, which may increase the likelihood of HIV transmission [17,19,22]. The gene discussed is CD4; the disease is sexually transmitted disease.