Ang II–induced hypertension is associated with increased interstitial and perivascular fibrosis,31 increased expression of remodeling proteins and enzymes, and elevated levels of pathological collagens.32 Cardiac fibrosis was assessed in the left ventricular using Masson trichrome (for global collagen deposition; Figure 5A) and picrosirius red (for fibrillar collagens; Figure 5B). The gene discussed is AGT; the disease is hypertensive disorder.