PI3Kγ expression on B16F10 melanoma cells promotes metastasis to the lungs of mice suffering from melanoma caused via the injection of B16F10 cells to their tail veins through increasing the expression of MMP-9, uPA, VEGF, HIF-1α, and HIF-2α by tumor-associated macrophages (TAMs) [26]. Here, MMP9 is linked to neoplasm.