Moreover, increased B7‐H3 expression is associated with increased probability of lymph node metastasis of HCC and B7‐H3 stimulation promotes metastasis through increasing the activity of MMP-2 and MMP-9 and targeting the EMT by the activation of JAK2/Stat3/Slug signaling pathway [19]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.