The systemic injection of endothelial progenitor cells derived from human induced pluripotent stem cells expressing CD40 by the use of baculovirus encoding CD40 ligand inhibits metastasis and induces prolonged survival through the formation of tumor necrosis factor-α (TNF-α) and IFN-γ in the 4T1 breast cancer lung metastasis model [53]. The gene discussed is IFNG; the disease is breast carcinoma.