HAVCR2 and Familial prostate cancer: The Tim-3 expression is improved on CD4+ T and CD8+ T cells isolated from the blood of patients afflicted by the lymph node, central nervous system, and bone metastasis of prostate cancer [118] and Tim-3 expression is also increased along with pulmonary metastasis stemming from prostate cancer and its expression augments metastasis by the stimulation of IL-6-STAT3 pathway [31].