HAVCR2 and Familial prostate cancer: Moreover, Tim-3 expression induces metastasis of HCC, ductal breast carcinoma, prostate cancer, and LAC through promoting macrophages into the M2-like phenotype [29], IL-6-STAT3 pathway [30], reducing the IFN-γ synthesis of peripheral NK cells [31], and triggering the NF-κB signaling [32], respectively.