IL6 and neoplasm: IL-6 induces immunosuppressive responses through STAT3 signaling and IL-6 synthesized by plasmacytoid DCs stimulates the monocytes to produce C–C motif chemokine ligand 2 (CCL2) which plays significant roles in the recruitment of myeloid-derived suppressor cells at the tumor site and M2 macrophage polarization and eventually promotes metastasis [13].