SYNPO2L and atrial fibrillation: Another interesting finding is about AF susceptibility loci in 10q22, which was reported as the first genetic locus for familial atrial fibrillation by Brugada R et al in 1997, and SNPs including rs10824026 [28, 44], rs7394190 [21], rs6480708 [17] and rs60212594 [17] in 10q22 and upstream of SYNPO2L gene were found robustly associated with AF in several GWAS project.