FMR1 and fragile X syndrome: Although changes in the eCB mobilization in FXS may explain some of the impairment (Jung et al., 2012; Maccarrone et al., 2010; Zhang and Alger, 2010), the role of FMRP in the regulation of local presynaptic protein synthesis may also play a role (but see Jung et al., 2012), although this remains to be tested (Busquets-Garcia et al., 2013).