In particular, in a mouse model of Fragile X Syndrome (FXS), the most common monogenic cause of autism, where RNA-binding protein, Fragile X mental retardation protein (FMRP) is deleted (Bagni and Zukin, 2019), eCB-mediated plasticity in the hippocampus, striatum, prefrontal cortex is impaired (Jung et al., 2012; Maccarrone et al., 2010; Martin et al., 2017; Wang et al., 2018b; Zhang and Alger, 2010). This evidence concerns the gene FMR1 and fragile X syndrome.