Moreover, to validate the influence of hub genes on GC prognosis, Kaplan‐Meier curve analysis was performed to analyze the correlation between the expression of the 10 hub genes (SKA1, ANLN, CHEK1, SKA3, TOP2A, BIRC5, RRM2, NCAPG2, FANCI, and RAD51) and the OS of patients with GC. The gene discussed is RRM2; the disease is gastric cancer.