Meanwhile, some genes have been found to associate with neurodevelopmental disorders (CASK and CHD8)50 or to be involved in synapse transmission, such as IGF1 (proband A3),51PIGG (proband A27),52SYP,53 and LAS1 L. 54Among those eight children, clinical improvements were observed in seven patients at different levels after BMMNC transplantation, whereas one patient (proband A27), who carried multiple genetic abnormalities, exhibited the least progress. The gene discussed is IGF1; the disease is neurodevelopmental disorder.