Furthermore, the expression pattern of FOXO1, SP1 and c‐JUN in glioma samples and the correlations between FOXO1, c‐JUN, SP1 and miR‐5188 levels suggested an vital role of miR‐5188 in glioma development through FOXO1, c‐JUN and SP1 dysregulation. This evidence concerns the gene SP1 and central nervous system cancer.