Patient 91 with c.850del in the KIDINS220 gene (NM_020738.2) showed failure to thrive, microcephaly, global developmental delay, mild dysmorphism, that is, not consistent with phenotype of Spastic paraplegia, intellectual disability, nystagmus, and obesity. This evidence concerns the gene KIDINS220 and obesity due to melanocortin 4 receptor deficiency.