A previous study observed lower levels of Bcl-2 in T cells of patients with HNSCC in comparison to healthy donors.18 Several studies, conducted in various conditions, reported that Bcl-2 and Bax are crucial for the survival and proliferation of several types of cells, such as CD4+ T, B, and natural killer (NK) cells.18-20. Here, BCL2 is linked to head and neck squamous cell carcinoma.