BCL2 and cancer: Bcl-2 and Bax expression is regulated by p53, a tumor suppressor gene.13 A previous study on cancer tissues found that the expression of Bax is strongly correlated with good clinical outcomes in HNSCC patients.14 Takemura and Noguchi15 (2002) corroborate with these results, reporting that patients with OSCC along with Bax expression had better prognosis than those without Bax expression.