The presence of a single-nucleotide polymorphism (SNP) at 6q25 among Hispanics/Latinas is associated with a lower risk of breast cancer, especially HR– subtypes.8,101,143 In addition, risk variants that are more common in women of African genetic ancestry have been reported to be associated with HR– disease.139,140 One of these SNPs is located within TERT (telomerase reverse transcriptase),139 a known cancer-susceptibility gene. The gene discussed is TERT; the disease is breast carcinoma.