A parallel MTA1 ChIP-seq data (GSE91687) from MCF-7 breast cancer cell line in the ENCODE project32 generated significant overlap with our data from HCT116 in promoter-binding genes (−5K to 2 K relative to TSS) (Supplementary Fig. 3d, p-value = 5.62e − 88, hypergeometric test). This evidence concerns the gene MTA1 and breast carcinoma.