For example, the result shows that proteins associated with CRP, white blood cell (WBC) count, neutrophil particles (Neut) and Cystatin C (CystC) are involved in the immune system, while some well-known obesity-related pathways like PI3K/Akt, JAK/STAT, RAP1, and MAPK signaling pathways were identified in weight, BMI, waist, and fat associated proteins42. Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.