Recently, Hu et al.176 have showed that culling-ring ubiquitin ligase 4 (CRL4) could regulate the expression of BIRC3 (one of the inhibitors of apoptosis proteins) through STAT3 pathway, and BIRC3 is associated with cisplatin-resistance in ovarian cancer cells, suggesting the potential functional role of CRL4 and BIRC3 as novel therapeutic targets for cisplatin-resistant patients. This evidence concerns the gene BIRC3 and ovarian carcinoma.