FZD10 and ovarian carcinoma: Inhibition of m6A demethylases FTO and ALKBH5 was found to effectively overcome PARP inhibitor resistance in BRCA-mutated epithelial ovarian cancers.67 Mechanistically, deletion of m6A erasers increased FZD10 mRNA m6A modification and led to stabilization of FZD10 and upregulation of the Wnt/beta-catenin signaling pathway.67