In the process of microRNAs (miRNAs) maturation, the stem-loop secondary structure adopted by primary transcripts of miRNA genes (pri-miRNAs) and miRNA precursors (pre-miRNAs) enable the interactions between the A-to-I editing machinery and the miRNA biogenesis pathway.40 ADARs can suppress miRNA maturation, which is another mechanism of gene regulation causing drug resistance.41 In leukemia, ADAR1-mediated miRNA editing impaired let-7 biogenesis and enhanced the self-renewal of leukemic stem cell (LSC). Here, ADAR is linked to leukemia.