METTL3 and cancer: Most studies focused on the regulation of the transcripts that participated in the maintenance and modulation of the stemness and self-renewing CSCs that are thought to be responsible for complex tumor heterogeneity, cancer progression and therapeutic resistance.59–61 SOX2 is one of the major regulators in tumor initiation and cancer stem-cell functions.62 One Study showed that m6A writer METTL3 interacted with the 3′UTR of SOX2 mRNA and lead to methylation and stabilization of SOX2 mRNA in glioma stem-like cells (GSCs).