MiR-150 decreased IC50 of gefitinib, downregulated the expressions of target gene NOTCH3, which was positively correlated with collagen 1A1 expression, providing a potential therapeutic target for LUAD treatment.90 Bone morphogenetic protein 4 (BMP4) accelerates cancer cell energy metabolism and is upregulated in the EGFR-TKI-resistant cells. This evidence concerns the gene BMP4 and cancer.