LOX and pulmonary fibrosis: The Role of lysyl oxidases in pathogenesis of pulmonary emphysema Lysyl oxidases regulate fibrillar collagen remodeling in idiopathic pulmonary fibrosis(Tjin et al. 2017) The copper-dependent lysyl oxidases play a role in the formation and accumulation of elastic fibers in the extracellular matrix and augments Pulmonary emphysema in COPD (Besiktepe et al. 2017).