The Role of lysyl oxidases in pathogenesis of pulmonary emphysema Lysyl oxidases regulate fibrillar collagen remodeling in idiopathic pulmonary fibrosis(Tjin et al. 2017) The copper-dependent lysyl oxidases play a role in the formation and accumulation of elastic fibers in the extracellular matrix and augments Pulmonary emphysema in COPD (Besiktepe et al. 2017). Here, LOX is linked to idiopathic pulmonary fibrosis.