These include AD rare mutations in APP, PSEN1, and PSEN2 genes [324]; PD-specific genetic markers (e.g., in SNCA, LRRK2, PRKN, UCHL1, PINK1, DJ-1, NR4A, see Abbreviation List) [324]; ALS genetic mutations in more than a dozen genes that have been found to cause familial ALS (ALS2, NEFH, FUS, TARDBP, C9orf72, and SOD1 [325], see Abbreviation List); and the HD characteristic mutation in the Huntingtin gene [324]. The gene discussed is APP; the disease is Alzheimer disease.