The toxicity of misfolded and aggregated proteins is well-established, as it was observed in different neurodegenerative diseases (i.e., Aβ peptide in AD, α-Synuclein in PD, and Huntingtin in HD), and even though it occurs in different brain regions for each disease, confirms a crucial role of the toxicity of macromolecules accumulation in these disorders [300]. The gene discussed is HTT; the disease is Alzheimer disease.