NLRP3 and Mental deterioration: Finally, in a recent work, Ising et al. [271] have demonstrated that the inhibition of the NLRP3 (see the Abbreviation List) inflammasome activity in mouse models significantly reduced Tau phosphorylation in different brain regions and prevented cognitive decline, thus indicating that the NLRP3 inflammasome may have an important role in AD pathophysiology [271].