Increased levels of lysosomal proteins (i.e., CatD and Lysosomal-Associated Membrane Protein 1, LAMP1) and decreased levels of synaptic proteins (synaptophysin, synaptopodin, synaptotagmin-2, and neurogranin) were also observed in the neural-derived plasma exosomes of AD patients [247] (Figure 6). The gene discussed is LAMP1; the disease is Alzheimer disease.