As mentioned above, a greater number of DEGs (152 of 201) turned out to be downregulated in CR compared to CIN, with many known tumor suppressor genes (AR, PGR, FAT4, PTCH1, TGFBR3, HOPX, SASH1, CRYAB, CFTR, and CLCA4) or candidate tumor suppressor genes (PTPRM, PTPRU, SLIT2, LMO7, NEGR1, AIF1L, DEPTOR, and RHCG) found among them. This evidence concerns the gene PTCH1 and neoplasm.