In our search for genes differently expressed between early invasive carcinoma and pre-invasive cervical neoplasms, significant downregulation of UNC5C (netrin receptor), SLIT2/3 (ligands for the ROBO receptors), and EPHA3 (ephrin receptor type A), and upregulation of EPHB2 (ephrin receptor type B) were identified in invasive cervical cancer (FDR < 0.05). The gene discussed is EPHB2; the disease is cervical cancer.