Inside the CK (+) subset, the proportion of EpCAM (+) cells, being first increased (in CIN1), tended to decrease in high-grade CIN and cancer, indicating that the development of invasive cervical carcinoma may be accompanied with expansion of cells that lose their EpCAM expression, whilst preserve cytokeratins, which could be considered as a sign of the EMP program, rather than full EMT program (Figure 15) [16]. This evidence concerns the gene EPCAM and cervical squamous intraepithelial neoplasia.