KRT8 and neoplasm: Interestingly, in a study by Pan et al. [112] on circulating tumor cells (CTCs) from patients with cervical cancer of I–II stages, a high overall prevalence of CTCs with EpCAM(+)CK8(+) epithelial phenotype (especially in stage I) and a presence of CTCs exhibiting a mixed phenotype were described, with the incidence of the latter being increased with the stage progression and with bigger depth of stromal invasion and pelvic lymph nodes involvement, illustrating the epithelial-mesenchymal phenotypic plasticity of cervical cancer cells capable of invasion and metastasis at early clinical stages.