Although this was done on the example of a remarkable change in intensity and distribution of immunohistochemical expression of single markers (PD1L and Ki67, in one work, and podoplanin, in another work), it is reasonable to assume this switch may engage a large number of genes responsible for regulation of angiogenesis, EMT, and invasion, which can be discovered by means of transcriptome profiling of pre-invasive and early invasive carcinoma. Here, PDPN is linked to invasive carcinoma.