Inverse relationship we observed between the relative abundance of TILs and the proportion of VEGFR3/FLT4 (+) and HGFR/MET (+) cells may imply the immune system actively participates in controlling (lymph-)angiogenesis and EMT during transition from intraepithelial neoplasia to early invasive/microinvasive carcinoma. Here, MET is linked to intraepithelial neoplasia.