Concomitantly with the observed changes in the expression of angiogenesis-/EMT-regulating genes, a number of epidermal differentiation markers (namely, CSTA, CSTB, CRNN, DMKN, DSG1, EPGN, KLKs 7, 8, 13, KRT13, PPL, PPP1R3C, SBSN, SCEL, SPINK5, SPINK7, SPRR2A, SPRR3, TMPRSS11B, TMPRSS11E, and TGM1) were, as anticipated, significantly repressed in CR samples compared to CIN (Table S2). The gene discussed is SPRR2A; the disease is cervical squamous intraepithelial neoplasia.