The WNT signaling pathway, with three specific genes (HMGB2, CD24, and DKK1, all being widely discussed in connection with the regulation of EMT and tumor cell invasion) found to be perturbed in early-stage invasive cervical cancer, has also been proved a major HPV target, along with the p53 and Rb pathways [67]. This evidence concerns the gene HMGB2 and cervical carcinoma.