Curiously enough, comparison of transcriptomes of pre-invasive and early invasive cervical cancer revealed virtually no significant “classical” promoters of angiogenesis/lymphangiogenesis conventionally used to describe “angiogenic/lymphangiogenic switch”, such as members of VEGF/VEGFR-, FGF/FGFR-, and PDGF/PDGFR families; angiopoietins; and proangiogenic (ETS and HIF) and pro-lymphangiogenic (PROX1, SOX18, and FOXC2) transcription factors. The gene discussed is SOX18; the disease is cervical cancer.