In spite of the fact that this inactivation can be detected in earlier, premalignant, lesions, the most significant increase in percentage of promoter hypermethylation of both SLIT2 and SLIT3 occurs, according to Narayan et al., when high-grade intraepithelial neoplasia progresses into invasive cervical carcinoma [29], our expression data being in line with these findings. The gene discussed is SLIT3; the disease is intraepithelial neoplasia.