The WNT signaling pathway, with three specific genes (HMGB2, CD24, and DKK1, all being widely discussed in connection with the regulation of EMT and tumor cell invasion) found to be perturbed in early-stage invasive cervical cancer, has also been proved a major HPV target, along with the p53 and Rb pathways [67]. The gene discussed is RB1; the disease is cervical carcinoma.