PML and viral infectious disease: Importantly, some of these proangiogenic and/or pro-EMT DNA-interacting factors identified as DEGs (e.g., MYBL2/B-Myb and DNMT1) are known to be directly incorporated into viral mechanisms of carcinogenesis or to be the components of DNA-sensing and DNA-damage response pathways, thereby serving as mediators of inflammation and viral infection recognition (e.g., PML), along with other cytosolic factors (e.g., STMN1 and LAPM3) also found to be upregulated in CR samples (Figure 8) [25,26,27].