Concomitantly with the observed changes in the expression of angiogenesis-/EMT-regulating genes, a number of epidermal differentiation markers (namely, CSTA, CSTB, CRNN, DMKN, DSG1, EPGN, KLKs 7, 8, 13, KRT13, PPL, PPP1R3C, SBSN, SCEL, SPINK5, SPINK7, SPRR2A, SPRR3, TMPRSS11B, TMPRSS11E, and TGM1) were, as anticipated, significantly repressed in CR samples compared to CIN (Table S2). This evidence concerns the gene SPINK5 and cervical squamous intraepithelial neoplasia.