LRRK2 and Parkinson disease: PPMI is a cohort of 423 de novo idiopathic PD patients, 196 healthy controls, 64 subjects with scans without evidence of dopaminergic deficit, 65 patients with PD risk factors of hyposomnia and sleep disorder, and 645 genetic cases (372 LRRK2, 246 GBA, 27 SNCA mutation carriers).