While mining patient databases probing for GSEA signatures potentially related to heparanase-mediated control of chromatin organization and gene expression, we discovered that sets of genes that regulate stability and activity of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are enriched in patients diagnosed with smoldering myeloma or myeloma (Figure 3A). Here, HPSE is linked to plasma cell myeloma.