In an effort to identify the molecular causes of their reported antineoplastic properties, several withanolides were isolated from these plants and reported to have potent anti-proliferative activities in cancer cells [18], which may be due to their ability to induce apoptosis as well as the expression of tumor necrosis factor-α (TNF-α) activated nuclear factor-κB (NF-κB) [19]. The gene discussed is TNF; the disease is cancer.