On the basis of this evidence, we investigated the ability of glutamate to recover oxidative metabolism, cell viability and intracellular Ca2+ dysfunctions in an in vitro model of PD based on retinoic acid (RA)-differentiated SH-SY5Y neuroblastoma dopaminergic cells exposed to α-syn plus Rot treatment [22], and explored the possible involvement of NCX1 and EAAT3. The gene discussed is SLC8A1; the disease is Parkinson disease.