BAY 41-2272 is a regular non-nitric oxide (NO)-based sGC stimulator and is used to ameliorate the fibrosis in the lung, systemic sclerosis, peritoneal stripping, pulmonary hypertension, cardiomyocyte hypertrophy, and chronic renal disease [24,25,26,27,28,29]. Here, SGCB is linked to pulmonary arterial hypertension.