In this sense, many proteins involved in vesicular transport (secretogranin II (SCG2), chromogranin A (CHGA)), in synapses formation and stabilization (neurexins (NRXNs), neuronal pentraxin 1 (NPTX1), neurocan core protein (NCANP)), and in the immune system (lysozime C (LysC) and β2-microglobulin (β2M)) were significantly higher in the CSF of patients with MCI, especially in patients with MCI progressing to AD pathology than in AD and healthy control patients [46]. This evidence concerns the gene NPTX1 and Alzheimer disease.