Four assessed neurotrophic factors (hepatocyte growth factor, fibroblast growth factors 2 and 13, and type 1 insulin-like growth factor) were significantly lower in CSPG4 neuronal precursor cells-derived BEVs from preclinical AD patients, being able to use these neurotrophic factors as early biomarkers of AD. Here, FGF2 is linked to Alzheimer disease.