The lesions of Alzheimer’s disease (AD) include pathological changes in the brain such as the accumulation of proteins (amyloid-β (Aβ) peptide and Tau); the degeneration of neurons and synapses, most noticeably in the neocortex and the hippocampus, which leads to structural changes as well as to the loss of functional connectivity, and the alterations of reactive processes like neuroinflammation and plasticity, related to oxidative stress and mitochondrial dysfunction [1]. The gene discussed is MAPT; the disease is Alzheimer disease.