The antitumor effects of palbociclib, a CDK4/6 inhibitor, and listinib, an inhibitor of insulin receptor and insulin growth factor receptors, were examined using PDOXs of Ewing’s sarcoma with Fusion involved in t(12;16) in malignant liposarcoma-ETS-related gene fusion and cyclin-dependent kinase inhibitor 2A/B loss [88]. The gene discussed is CDK4; the disease is Ewing sarcoma.