However, the mechanisms explaining the Bacteroidetes modulation of the bodyweight remain still unclear, even though a recent experiment on mice has suggested that the anti-obesity properties may be connected with the production of succinate and secondary bile acids, which activate the intestinal farnesoid X receptor (FXR) signaling pathway, with a consequent stimulation of intestinal gluconeogenesis, along with the increase in the gut barrier integrity [31]. This evidence concerns the gene NR1H4 and obesity due to melanocortin 4 receptor deficiency.