Metabolically obese, normal-weight Asians have 20–30% lesser insulin sensitivity and 30–40% higher fasting and postprandial insulin secretion than metabolically healthy, lean controls [14] Among Japanese men with BMI of 23–25 kg/m2, those with hypertension, hyperglycemia, or dyslipidemia have insulin resistance in the liver but less insulin resistance in the muscle. Here, INS is linked to Hypertension.