Recently, the authors disclosed that the NGS-based targeted resequencing of the known 134 deafness genes does not necessarily guarantee the accurate detection of causative variants, particularly, the major allele (p.Arg1939Gln) of Korean ANSD with prelingual onset, due to capture failures and poor coverage of the last exon of the cochlear isoforms of OTOF [14,15]. This evidence concerns the gene OTOF and deafness.