In a mouse model for acute myocardial infarction, the treatment of intravenous transplantation using human umbilical cord blood mesenchymal stem cells by modulating the conversion of macrophage subtype M1/M2 reduced the inflammatory response, decreased the serum Gal-3 level, improved cardiac function and protected the infarcted myocardium [108]. This evidence concerns the gene LGALS3 and acute myocardial infarction.