In cancer cells, VEGF165, a splice variant of VEGF-A, upregulates sVEGFR-1 in cooperation with the transcription factor SRY-box transcription factor 2 (SOX2) and the splicing factor serine/arginine-rich splicing factor 2 (SRSF2) [31]; however, VEGF165 has no effect on sVEGFR-1 production in HMVEC [24]. Here, SOX2 is linked to cancer.