CXCL8 and periodontal disorder: Septic arthritis [120,121], periodontal disease [122,123,124]. Cell membranes of Mycoplasma salivarium promote expression of IL-6 and IL-8 in human fibroblasts through stimulation of protein kinase C (PKC) in Gin-1 cells, a human gingival fibroblast cell line [125].