TNF and Mycoplasma pneumoniae pneumonia: Similar pathogenetic mechanisms can be supposed for early-onset CNS disease related to Mycoplasma pneumonia, since concentrations of interleukin IL-6, IL-8, IL-18, interferon (INF)-g, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β1 are increased in serum of CSF samples from patients with several CNS manifestations during acute Mycoplasma pneumoniae infection [75].