To this regard, p37 increased migration in a transwell (Matrigel) assay of human gastric carcinoma (AGS) cells by inducing the phosphorylation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase and the activity of matrix metalloproteinase-2 (MMP-2) [161].These results indicate that p37 may be able to promote invasion by upregulating the activity of MMP-2; thus, causing EGFR phosphorylation and increasing tumor metastasis upon Mycoplasma hyorhinis infection. This evidence concerns the gene MMP2 and gastric carcinoma.