LCN2 and Alzheimer disease: Interestingly, Shiratori-Hayashi et al. [54] reported the probable role of lipocalin-2 in the itch sensation in a mouse model of AD, finding that the protein activates the signal transducer and activator of transcription 3-dependent differentiation of astroglia in the posterior horns of the spinal cord, which is responsible for the enhancement of itch.