Given that 4F has superior lipid-binding affinity compared to 18A [169], it would be interesting to determine whether combining 4F with the receptor-binding region of APOE, to create Ac-hE-4F-NH2, produces more robust protective effects than Ac-hE-18A-NH2 or 4F alone, in AD mouse models. The gene discussed is APOE; the disease is Alzheimer disease.