In addition to APOE, CLU, and ABCA7, well-known genes that are intimately involved in lipid/cholesterol metabolism and AD pathogenesis, many other genes involved in protein-lipid complex assembly, reverse cholesterol transport, and plasma lipoprotein/HDL particle assembly pathways have been shown to influence the risk of AD [7,8,9]. This evidence concerns the gene ABCA7 and Alzheimer disease.