TNF and cancer: It is well known that angiogenesis plays an essential role in the progression of cancer; IMiDs also have an anti-angiogenetic effect, reducing tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), fibroblast growth factor-β (FGF-β) and interleukin-6 (IL-6) (Figure 2) [16].