Thus, different cell surface molecules are needed to allow PRRSV interaction, entry, and infection of cells: porcine sialoadhesin—also known as sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1) or CD169, Siglec-10, CD151, MYH9, and heparan sulfate [38,39,40] have been shown to mediate the interaction of PRRSV with cells; however, only CD163 has been demonstrated as essential for PRRSV genome delivery from endosome to the cytosol of the cells [41] and replication in the porcine host [42]. The gene discussed is CD163; the disease is infection.