Although its effect has not been investigated in prostate cancer, existing literature shows that asparagine synthetase is a target in castration-resistant prostate cancer, and prostate cancer cells are especially sensitive to arginine deprivation because they lack argininosuccinate synthetase (ASS), the rate-limiting biosynthetic enzyme responsible for intracellular arginine synthesis [50,51]. Here, ASS1 is linked to Familial prostate cancer.