Increased AR expression was also correlated with a number of dysregulated gene signatures in other cancers: genes down-regulated in metastatic versus non-metastatic head and neck squamous cell carcinoma samples, genes down-regulated by the expression of HBV X protein, genes down-regulated in genomically unstable Ewing’s sarcoma tumors compared to the stable ones, genes down-regulated in SW480 cells (colon cancer with mutated p53 upon expression of BRCA1 off an adenovirus vector), and genes under-expressed in stem cell-like cholangiocellular carcinoma. The gene discussed is PSMB5; the disease is Ewing sarcoma.